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Note: If you have a family history of a certain type of thyroid cancer (medullary thyroid carcinoma, or MCT), you should not use GLP-1 medications

Participants received tirzepatide or placebo for 72 weeks (Jastreboff et al., NEJM 2022)

GCGR/GLP-1R agonist: OR: 0.23, 95%CI: 0.070.75, P = 0.02

This third mechanism is what separates retatrutide from tirzepatide and likely explains the additional ~2% weight loss seen in trials

So that's often a huge challenge and can be very distressing for patients," says Francavilla, who is sometimes paid by drugmaker Eli Lilly to educate other health professionals about how its obesity medicines work

This effect has been shown to help people eat less and steadily lose pounds